Asiaticoside counteracts the in vitro activation of microglia and astrocytes: Innuendo for multiple sclerosis
During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage. In this study, we have explored the action of Asiaticoside A against the ac...
Saved in:
Published in | Biomedicine & pharmacotherapy Vol. 107; pp. 303 - 305 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
France
Elsevier Masson SAS
01.11.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage.
In this study, we have explored the action of Asiaticoside A against the activated microglia and astrocytes.
Primary microglia and astrocyte cultures were used for the study and the activity were evaluated using cell proliferation assay, nitrate assay and TNFα estimation using ELISA.
Asiaticoside A inhibited the production of nitric oxide and TNFα in LPS activated primary microglia and astrocyte cultures.
This study suggests that Asiaticoside A may be effective against the progression of MS. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0753-3322 1950-6007 |
DOI: | 10.1016/j.biopha.2018.08.010 |