Asiaticoside counteracts the in vitro activation of microglia and astrocytes: Innuendo for multiple sclerosis

During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage. In this study, we have explored the action of Asiaticoside A against the ac...

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Bibliographic Details
Published inBiomedicine & pharmacotherapy Vol. 107; pp. 303 - 305
Main Authors Madhu, Krishnadas, T, Prakash
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.11.2018
Subjects
Animals
Asiaticoside
Astrocyte
Astrocytes - drug effects
Astrocytes - pathology
Cells, Cultured
Lipopolysaccharides
Mice, Inbred C57BL
Microglia
Microglia - drug effects
Microglia - pathology
Multiple Sclerosis
Multiple Sclerosis - pathology
Primary cell culture
Triterpenes - pharmacology
Multiple Sclerosis
TNFα
MS
CNS
PDL
Astrocyte
LPS
Asiaticoside
Microglia
Primary cell culture
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Summary:During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage. In this study, we have explored the action of Asiaticoside A against the activated microglia and astrocytes. Primary microglia and astrocyte cultures were used for the study and the activity were evaluated using cell proliferation assay, nitrate assay and TNFα estimation using ELISA. Asiaticoside A inhibited the production of nitric oxide and TNFα in LPS activated primary microglia and astrocyte cultures. This study suggests that Asiaticoside A may be effective against the progression of MS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2018.08.010