Advancing personalized medicine: Integrating statistical algorithms with omics and nano-omics for enhanced diagnostic accuracy and treatment efficacy

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1870; no. 7; p. 167339
• Main Authors: Coskun, Abdurrahman, Ertaylan, Gökhan, Pusparum, Murih, Van Hoof, Rebekka, Kaya, Zelal Zuhal, Khosravi, Arezoo, Zarrabi, Ali
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2024
• Subjects: Algorithms; Genomics; Genomics - methods; Global health; Humans; Metabolomics; Metabolomics - methods; Nano-omics; Nanotechnology - methods; Personalized medicine; Precision Medicine - methods; Proteomics - methods; LL; CVT; Metabolomics; EFLM; RCV; Genomics; popDL; DL; prRI; ctDNA; BV; popRI; UL; popRC; prRCV; MI; II; CLSI; Global health; AD; HSP; MS; AL; Personalized medicine; CVA; NMR; CTC; CVG; CVI; RI; PI; pDL; CVP; Nano-omics; PET; HF; DC
• ISSN: 0925-4439; 1879-260X; 1879-260X
• DOI: 10.1016/j.bbadis.2024.167339

Medical laboratory services enable precise measurement of thousands of biomolecules and have become an inseparable part of high-quality healthcare services, exerting a profound influence on global health outcomes. The integration of omics technologies into laboratory medicine has transformed healthcare, enabling personalized treatments and interventions based on individuals' distinct genetic and metabolic profiles. Interpreting laboratory data relies on reliable reference values. Presently, population-derived references are used for individuals, risking misinterpretation due to population heterogeneity, and leading to medical errors. Thus, personalized references are crucial for precise interpretation of individual laboratory results, and the interpretation of omics data should be based on individualized reference values. We reviewed recent advancements in personalized laboratory medicine, focusing on personalized omics, and discussed strategies for implementing personalized statistical approaches in omics technologies to improve global health and concluded that personalized statistical algorithms for interpretation of omics data have great potential to enhance global health. Finally, we demonstrated that the convergence of nanotechnology and omics sciences is transforming personalized laboratory medicine by providing unparalleled diagnostic precision and innovative therapeutic strategies. [Display omitted] •Medical laboratories profoundly impact global health outcomes.•Omics technologies have transformed personalized treatments and interventions.•Individual omics data should be interpreted using personal references.•Personalized reference intervals for omics data are essential for global health.