Coexistence of xeroderma pigmentosum with sarcoidosis and adenocarcinoma of the digestive organs

• Published in: Acta dermato-venereologica Vol. 80; no. 5; pp. 376 - 377
• Main Authors: OKADA, Mikiko, TANAKA, Misako, HORIUCHI, Norihisa, KATO, Taizo, TAGAMI, Hachiro
• Format: Journal Article
• Language: English
• Published: Uppsala Acta dermato-venereologica 01.09.2000
• Subjects: Adenocarcinoma - complications; Adenocarcinoma - pathology; Biological and medical sciences; Carcinoma, Basal Cell - complications; Carcinoma, Basal Cell - pathology; Carcinoma, Squamous Cell - complications; Carcinoma, Squamous Cell - pathology; Colonic Neoplasms - complications; Colonic Neoplasms - pathology; Dermatology; Female; Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue; Humans; Lymph Nodes - pathology; Medical sciences; Middle Aged; Sarcoidosis - complications; Sarcoidosis - pathology; Skin - pathology; Skin Diseases - complications; Skin Diseases - pathology; Skin Neoplasms - complications; Skin Neoplasms - pathology; Xeroderma Pigmentosum - complications; Xeroderma Pigmentosum - pathology; Adenocarcinoma; Human; Photosensitivity; Skin disease; Pigmentation disorder; Sarcoidosis; Digestive system; Xeroderma pigmentosum; Malignant tumor; Genetic disease; Case study; Photodermatosis; Systemic disease; Digestive diseases; Organ
• ISSN: 0001-5555; 1651-2057
• DOI: 10.1080/000155500459358

Xeroderma pigmentosum has not been reported in association with any specific diseases except for skin malignancy. We observed a case of its coexistence with sarcoidosis and adenocarcinoma of the digestive organs, which has been reported only once in the past. A 54-year-old Japanese female with a variant type of xeroderma pigmentosum developed successively multiple lesions of basal cell carcinoma and squamous cell carcinoma on her face. Intensive metastasis studies led to the incidental detection of non-caseating epithelioid cell granulomas in one of the palpable right supraclavicular lymph nodes. Similar granulomas were also revealed in the excised tissue specimen of squamous cell carcinomas of her left cheek. She was also found to have bilateral hilar lymphadenopathy and chronic uveitis. Three years later, she died of colon adenocarcinoma and its liver metastasis.