Neurohypophysial peptides selectively depressed high voltage-activated Ca-current in snail neurons

It was found that neurohypophysial peptides oxytocin and Lys-vasopressin selectively decreased the high voltage-activated component of the inward Ca-current in voltage-clamped Helix pomatia identified neurons in a dose- and time-dependent manner. This effect was unaffected or further enhanced applyi...

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Bibliographic Details
Published inNeuroscience letters Vol. 120; no. 1; p. 9
Main Authors Osipenko, O N, Kiss, T
Format Journal Article
LanguageEnglish
Published Ireland 27.11.1990
Subjects
Animals
Barium - pharmacology
Caffeine - pharmacology
Calcium Channels - drug effects
Calcium Channels - physiology
Ganglia - physiology
Helix (Snails)
In Vitro Techniques
Lypressin - pharmacology
Membrane Potentials - drug effects
Neurons - drug effects
Neurons - physiology
Oxytocin - pharmacology
Phosphodiesterase Inhibitors - pharmacology
Theophylline - pharmacology
Xanthines - pharmacology
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Summary:It was found that neurohypophysial peptides oxytocin and Lys-vasopressin selectively decreased the high voltage-activated component of the inward Ca-current in voltage-clamped Helix pomatia identified neurons in a dose- and time-dependent manner. This effect was unaffected or further enhanced applying phosphodiesterases inhibitors. It is suggested that suppression of high voltage-activated current was due to the activation of the adenylate cyclase system, likely protein kinase A.
ISSN:0304-3940
DOI:10.1016/0304-3940(90)90155-3