The change in kidney function was associated with carotid artery plaque in a community-based population: A cohort study

• Published in: Nutrition, metabolism, and cardiovascular diseases Vol. 31; no. 1; pp. 119 - 126
• Main Authors: Xu, Renying, Cai, Hong, Fan, Zhuping, Wan, Yanping, Gao, Xiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 04.01.2021
• Subjects: Adult; Adults; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - epidemiology; Carotid artery plaque (CAP); China - epidemiology; Chronic kidney disease; Estimated glomerular filtration rate (eGFR); Female; Glomerular Filtration Rate; Humans; Kidney - physiopathology; Kidney Diseases - diagnosis; Kidney Diseases - epidemiology; Kidney Diseases - physiopathology; Male; Middle Aged; Plaque, Atherosclerotic; Prognosis; Risk Assessment; Risk Factors; Time Factors; China; Estimated glomerular filtration rate (eGFR); Chronic kidney disease; Adults; Carotid artery plaque (CAP)
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2020.08.016

We performed the current study to evaluate the association between dynamic change in estimated glomerular filtration rate (eGFR) and the risk of carotid artery plaque (CAP) in a community-based population. A total number of 37,093 Chinese adults (21,790 men and 15,303 women, aged 42.6 ± 11.6 years) free of chronic kidney diseases were enrolled. The change in eGFR was calculated based on two measurements in 2013 and 2014 (mean interval: 1.2 y). Participants were further classified into three groups based on the change in eGFR: fast-decrease (<-3.3%), stable (from −3.3% to 3.3%), and fast-increase (≥3.3%). CAP was annually assessed by ultrasound B model throughout the study (2013–2018). We have identified 1,624 new cases of CAP (16.0 per 1000 person-year) during follow up. Compared to participants with stable eGFR, participants in both fast-decrease and fast-increase groups were associated with 1.99 folds (HR = 1.99, 95% CI: 1.54, 2.57) and 3.15 folds (HR = 3.15, 95% CI: 2.38, 4.16) higher likelihood of developing CAP. The association between continuous change in eGFR and the risk of CAP demonstrate a “U” shape. Sensitivity analysis generated similar results with main analysis. Both fast decrease and increase in eGFR were associated with the risk of developing CAP in Chinese adults.