Production of humoral factors that stimulate spleen colony-forming units in mice irradiated with moderate doses of X rays

The production of humoral factors that stimulate spleen colony-forming units (CFU-S) has been studied in irradiated mice using an in vivo diffusion chamber assay. The experiments show that a significant release of factors that stimulate CFU-S takes place in the first few days after irradiation with...

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Bibliographic Details
Published inRadiation research Vol. 122; no. 1; p. 53
Main Authors Grande, T, González, J, Tejero, C, Maganto, G, Bueren, J A
Format Journal Article
LanguageEnglish
Published United States 01.04.1990
Subjects
Animals
Antibodies - immunology
Antibody Formation
Cell Division - radiation effects
Diffusion Chambers, Culture
Endotoxins - blood
Female
Mice
Mice, Inbred Strains
Radiation Dosage
Spleen - cytology
Spleen - immunology
Spleen - radiation effects
Stem Cells - cytology
Stem Cells - immunology
Stem Cells - radiation effects
Thymidine - metabolism
Time Factors
Whole-Body Irradiation
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Summary:The production of humoral factors that stimulate spleen colony-forming units (CFU-S) has been studied in irradiated mice using an in vivo diffusion chamber assay. The experiments show that a significant release of factors that stimulate CFU-S takes place in the first few days after irradiation with moderate doses of 1.5 or 5 Gy. In contrast, the release of significant amounts of these humoral factors was not seen in animals irradiated with either low (0.75 Gy) or high (10 Gy) doses of X rays. The correlation observed between the production of factors that stimulate the CFU-S and the hemopoietic regeneration kinetics of the irradiated mice suggests that these factors represent part of the physiological regulators controlling the proliferation of CFU-S.
ISSN:0033-7587
DOI:10.2307/3577582