Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity

• Published in: Bioorganic chemistry Vol. 60; pp. 118 - 122
• Main Authors: Mesaik, M. Ahmed, Khan, Khalid Mohammed, Rahim, Fazal, Taha, Muhammad, Haider, Syed Moazzam, Perveen, Shahnaz, Khalid, Ahmed Shukralla, Abdalla, Omer M., Soomro, Samreen, Voelter, Wolfgang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2015
• Subjects: Adult; Animals; Cattle; Cell Line; Cell Proliferation - drug effects; Cytokine inhibition; Cytokines - immunology; Humans; Immunity, Cellular - drug effects; Immunologic Factors - chemistry; Immunologic Factors - pharmacology; Indole Mannich base; Indoles - chemistry; Indoles - pharmacology; Mannich Bases - chemistry; Mannich Bases - pharmacology; Nitric oxide; Nitric Oxide - immunology; Reactive Oxygen Species - immunology; ROS; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Cytokine inhibition; Indole Mannich base; Nitric oxide; ROS
• ISSN: 0045-2068; 1090-2120
• DOI: 10.1016/j.bioorg.2015.05.003

[Display omitted] •Indole Mannich base derivatives.•ROS.•Nitric oxide.•Cytokine inhibition. The synthetic indole Mannich bases 1–13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production.