Cushing's syndrome in pregnancy

• Published in: Gynecological endocrinology Vol. 31; no. 2; pp. 102 - 104
• Main Authors: Nassi, Rossella, Ladu, Cristina, Vezzosi, Chiara, Mannelli, Massimo
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.02.2015
• Subjects: Adrenalectomy; Adult; Cushing Syndrome - complications; Cushing Syndrome - surgery; Female; Humans; Pregnancy; Pregnancy Complications - surgery; hypercortisolism; Adrenal adenoma; hormonal change in pregnancy; pregnancy; hirsutism in pregnancy
• ISSN: 0951-3590; 1473-0766; 1473-0766
• DOI: 10.3109/09513590.2014.984680

Abstract Cushing's syndrome is a rare condition in the general population and is even less common during pregnancy with only a few cases reported in literature. The diagnosis of Cushing's syndrome may be difficult during pregnancy because the typical features of the disorder and pregnancy may overlap. However, Cushing's syndrome results in increased fetal and maternal complications, and diagnosis and treatment are critical. This report describes a case of 26-year-old female at the 19th week of pregnancy with symptoms and signs of hypercortisolism, where ACTH-independent Cushing's syndrome was diagnosed and treated by robotic laparoscopic adrenalectomy at the 21th week of gestation. Chinese abstract 库欣综合征在一般人群中呈稀发，而在妊娠期的库欣综合征则更为罕见，很少有文献报道。妊娠增加了库欣综合征诊断的难度，因为库欣综合征患者典型的临床表现可能与妇女在妊娠期的表现相重叠。然而，妊娠期的库欣综合征导致胎儿和孕母并发症几率升高，及时的诊断和治疗非常关键。这个报告描述了一个26岁妇女在其妊娠19周时出现的皮质醇增多症表现和临床症状，之后其被诊断为ACTH依赖性库欣综合征，并在妊娠21周时接受了机器人腹腔镜下肾上腺切除术。