Cytokines: The links between bone and the immune system

Osteoporosis results from an imbalance in a highly balanced physiological process called bone remodeling, in which osteoclast-mediated bone resorption and osteoblast-mediated bone formation play important roles. Osteoimmunology is a newly discovered interdisciplinary research field that focuses on t...

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Bibliographic Details
Published inInjury Vol. 55; no. 2; p. 111203
Main Authors Cai, Liping, Lv, You, Yan, Qihui, Guo, Weiying
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.02.2024
Subjects
Bone and Bones
Bone Remodeling
Bone Resorption
Cytokines
Cytokines - metabolism
Humans
Immune System - metabolism
Osteoblasts
Osteoblasts - metabolism
Osteoclasts
Osteoimmunology
Osteoimmunology
Osteoclasts
Cytokines
Osteoblasts
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Summary:Osteoporosis results from an imbalance in a highly balanced physiological process called bone remodeling, in which osteoclast-mediated bone resorption and osteoblast-mediated bone formation play important roles. Osteoimmunology is a newly discovered interdisciplinary research field that focuses on the relationship between bone and the immune system. Specifically, bone and the immune system interact through cytokines, immune cells secrete cytokines, and cytokines finely regulate bone metabolism by mediating the differentiation and activity of osteoclasts and osteoblasts. Therefore, understanding the influence of cytokines on bone metabolism is conducive for the development of novel targeted drugs against immune-related bone diseases. This review summarizes the pathophysiological functions of various common cytokines in bone and discusses the potential clinical value of multiple cytokines in immune-mediated bone diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0020-1383
1879-0267
DOI:10.1016/j.injury.2023.111203