Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development

In the dorsal horn of the chick embryo spinal cord, extracellular signal-regulated kinase (ERK) was phosphorylated transiently during embryonic days 6 and 9. Co-culture studies suggested that dorsal root ganglion (DRG) activated ERK in the dorsal horn. Brain-derived neurotrophic factor (BDNF) activa...

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Bibliographic Details
Published inNeuroscience research Vol. 58; no. 4; pp. 402 - 405
Main Authors Kato, Taro, Ohtani-Kaneko, Ritsuko, Shiga, Takashi
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.08.2007
Subjects
Animals
Antibodies - pharmacology
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - immunology
Brain-Derived Neurotrophic Factor - pharmacology
Chick Embryo
Dorsal horn
Dorsal root ganglion
Enzyme Activation - drug effects
Enzyme Activation - physiology
ERK
Extracellular Signal-Regulated MAP Kinases - metabolism
Ganglia, Spinal - physiology
In Vitro Techniques
MAP kinase
Spinal Cord - anatomy & histology
Spinal Cord - embryology
Spinal Cord - enzymology
Time Factors
MAP kinase
Brain-derived neurotrophic factor
Dorsal root ganglion
Dorsal horn
ERK
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Summary:In the dorsal horn of the chick embryo spinal cord, extracellular signal-regulated kinase (ERK) was phosphorylated transiently during embryonic days 6 and 9. Co-culture studies suggested that dorsal root ganglion (DRG) activated ERK in the dorsal horn. Brain-derived neurotrophic factor (BDNF) activated ERK in the dorsal horn, and anti-BDNF blocked the DRG-induced ERK activation. These results suggest roles of BDNF in the DRG-induced ERK activation in the embryonic dorsal horn.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2007.04.010