Treatment of Staphylococcus epidermidis Ventriculo–Peritoneal Shunt Infection with Linezolid

• Published in: The Journal of infection Vol. 45; no. 2; pp. 129 - 132
• Main Authors: Gill, C.J., Murphy, M.A., Hamer, D.H.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.08.2002; Elsevier
• Subjects: Acetamides - therapeutic use; Adult; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Device Removal; Female; Humans; Linezolid; Medical sciences; Meningitis, Bacterial - drug therapy; Meningitis, Bacterial - microbiology; Meningitis, Bacterial - therapy; Oxazolidinones - therapeutic use; Pharmacology. Drug treatments; Staphylococcal Infections - drug therapy; Staphylococcal Infections - therapy; Staphylococcus epidermidis; Ventriculoperitoneal Shunt; Human; Linezolid; Ventriculoperitoneal; Nervous system diseases; Intravenous administration; Treatment efficiency; Cerebrospinal fluid; Infection; Case study; Chemotherapy; Staphylococcus epidermidis; Treatment; Bypass; Central nervous system disease; Bacteriosis; Bacteria; Micrococcales; Complication; Meningitis; Micrococcaceae; Antibacterial agent; Staphylococcal infection
• ISSN: 0163-4453; 1532-2742
• DOI: 10.1053/jinf.2002.0979

Gram-positive bacterial meningitis frequently complicates ventriculo-peritoneal (VP) shunts used for hydrocephalus. Linezolid, an oxazolidinone, is active against Gram-positive cocci, and has excellent CSF penetration. We present a 22-year-old woman who was cured of a Staphylococcus epidermidis VP shunt infection via shunt removal and intravenous linezolid.