Effects of Additives contained in Injections on Coagulation and Fibrinolysis of Blood

Effects of six kinds of additives in injections, i. e. benzyl alcohol, HCO-60, macrogol 4000, urethan, sodium bisulfite and sodium sulfite, on the blood were investigated, and the following results were obtained ; 1) In the concentrations of additives contained in injections benzyl alcohol inhibited...

Full description

Saved in:
Bibliographic Details
Published inYAKUGAKU ZASSHI Vol. 103; no. 1; pp. 94 - 99
Main Authors KIMURA, MASAYUKI, YASUI, TOMOMI, SATOH, JUN, KUSUNOKI, ITSUMI, NAKAGAWA, TERUAKI, UENO, MASAHARU, HORIKOSHI, ISAMU, SAKURAGAWA, NOBUO
Format Journal Article
LanguageJapanese
English
Published Japan The Pharmaceutical Society of Japan 01.01.1983
Subjects
additives in injections
benzyl alcohol
Blood Coagulation - drug effects
coagulation
Depression, Chemical
fibrinolysis
Fibrinolysis - drug effects
HCO-60
Humans
Injections
macrogol 4000
Pharmaceutic Aids - adverse effects
platelet aggregation
Platelet Aggregation - drug effects
sodium bisulfite
sodium sulfite
urethan
Online AccessGet full text

Cover

More Information
Summary:Effects of six kinds of additives in injections, i. e. benzyl alcohol, HCO-60, macrogol 4000, urethan, sodium bisulfite and sodium sulfite, on the blood were investigated, and the following results were obtained ; 1) In the concentrations of additives contained in injections benzyl alcohol inhibited the platelet aggregation and the inorganic salts had the inhibitory effects on both the blood coagulational and fibrinolytic phenomena. The action of sodium bisulfite on the blood was recognized to be based on pH and that of sodium sulfite to be ascribed to SO32-. 2) The injections which contain both benzyl alcohol and sodium bisulfite as additives are commercially available. However, they are not evaluated to be desirable injections from the standpoints of hematology, especially of coagulation, fibrinolysis and platelet aggregation.
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.103.1_94