Characteristics and severity of preeclampsia in young and elderly gravidas with hypertensive disease

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 228; pp. 120 - 125
• Main Authors: Rymer-Haskel, Noa, Schushan-Eisen, Irit, Hass, Yigal, Rahav, Roni, Maayan-Metzger, Ayala, Hendler, Israel
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.09.2018
• Subjects: Adult; Advanced maternal age; Exacerbation; Female; Humans; Israel - epidemiology; Maternal Age; Middle Aged; Postpartum; Pre-Eclampsia - epidemiology; Preeclampsia; Pregnancy; Retrospective Studies; Young maternal age; Israel; Exacerbation; Young maternal age; Preeclampsia; Advanced maternal age; Postpartum
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2018.05.038

Advanced maternal age (AMA) is associated with increased risk for preeclampsia, however, a paucity of data exists regarding the characteristics of the disease in this age group. Our aim was to compare the characteristics and severity of preeclampsia in older and younger gravidas. A retrospective, small case control study of women diagnosed with preeclampsia in a single tertiary care center. Nulliparous women ≥40 years old with singleton pregnancies ≥ 24 0/7 weeks' gestation were matched (1:2 ratio) with young (20–34 years old) nulliparous women. The rate of severe preeclampsia (60.9 vs 69.6% respectively), HELLP, eclampsia or the need for magnesium treatment did not differ between the groups. However, the AMA group had an increased rate of postpartum presentation or exacerbation of preeclampsia compared to the control group (50.0 vs. 28.3% respectively, p = 0.01). In the AMA group, 93.5% of births were by cesarean section (CS) compared to 52.2% in the control group (p < 0.0001). There was no difference in birthweight, rate of small for gestational age or composite neonatal morbidity between the groups. Preeclampsia at an advanced maternal age carries a similar rate of severe preeclampsia and complications as in young women. However, women over 40 years old have an increased risk for presentation or exacerbation of preeclampsia in the postpartum period and an increased rate of CS compared to younger gravidas.