The effect of medicinal plants on multiple drug resistance through autophagy: A review of in vitro studies

Multiple drug resistance (MDR) often occurs after prolonged chemotherapy, leading to refractory tumor and cancer recurrence. Autophagy as a primarily process during starvation or stress has a bipolar nature in cancer. It can cause MDR to become more difficult or make resistant cancer cells more susc...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 852; pp. 244 - 253
Main Authors Sameiyan, Elham, Hayes, A. Wallace, Karimi, Gholamreza
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 05.06.2019
Subjects
Autophagy
MDR
Natural products
Natural products
Autophagy
MDR
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Summary:Multiple drug resistance (MDR) often occurs after prolonged chemotherapy, leading to refractory tumor and cancer recurrence. Autophagy as a primarily process during starvation or stress has a bipolar nature in cancer. It can cause MDR to become more difficult or make resistant cancer cells more susceptible to chemotherapeutic agents. A number of natural products have been introduced to drug discovery for many years. Some of these compounds have been shown to reverse drug resistance by different regulatory mechanisms. In this review, the focus is on the role of medicinal plants in the MDR phenomenon, primarily through the autophagy process. The effect of medicinal plants on multiple drug resistance and bipolar nature of autophagy process in MDR tumor cells [Display omitted]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2019.04.001