Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: Prevention of cognitive deficit and anxiety in Alzheimer’s disease model

• Published in: Biomedicine & pharmacotherapy Vol. 105; pp. 1006 - 1014
• Main Authors: Pinz, Mikaela P., dos Reis, Angélica S., Vogt, Ane G., Krüger, Roberta, Alves, Diego, Jesse, Cristiano R., Roman, Silvane S., Soares, Mauro P., Wilhelm, Ethel A., Luchese, Cristiane
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2018
• Subjects: Anticholinesterase; Antioxidant; Anxiety; Memory; Quinoline; Selenium; Quinoline; Anticholinesterase; Anxiety; Selenium; Antioxidant; Memory
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2018.06.049

[Display omitted] •PSQ protected against learning and memory impairment in Alzheimer’s disease model.•PSQ had anxiolytic action in an Alzheimer’s disease model.•PSQ had anticholinesterase action and antioxidant effect.•PSQ is a multi-target drug for Alzheimer disease. This study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) at a dose of 1 mg/kg in memory impairment and anxiety in an Alzheimer’s disease (AD) model induced by amyloid β-peptide (Aβ) (fragment 25–35) in mice. The involvement of acetylcholinesterase (AChE) activity and lipid peroxidation in hippocampus and cerebral cortex was evaluated. Male Swiss mice were pretreated with 4-PSQ (1 mg/kg, intragastrically (i.g.), daily) for fourteen days. Thirty minutes after the first treatment with 4-PSQ, the animals received a single injection of Aβ (3 nmol/3 μl/per site, intracerebroventricular (i.c.v.)). Mice were submitted to the behavioral tasks (open-field, elevated plus maze, Barnes maze, object recognition and location, and step-down inhibitory avoidance tests) from the fifth day onwards. On the fifteenth day, blood was removed for analysis of biochemical markers (glucose, triglycerides, urea, aspartate (AST) and alanine (ALT) aminotrasferases), and cerebral cortex and hippocampus for determination of AChE activity and thiobarbituric acid reactive species (TBARS) levels. Aβ caused memory impairment, anxiogenic behavior, increased AChE activity in the cerebral structures and TBARS levels in the cerebral cortex. 4-PSQ was effective to protect against behavioral changes, AChE activity and TBARS levels. In conclusion, 4-PSQ protected against learning and memory impairment and anxiety in a mouse model of AD induced by Aβ, and anticholinesterase and antioxidant actions are involved in the pharmacological effect of the compound.