Importance of genetic background of oxysterol signaling in cancer

• Published in: Biochimie Vol. 153; pp. 109 - 138
• Main Authors: Holy, P., Kloudova, A., Soucek, P.
• Format: Journal Article
• Language: English
• Published: France Elsevier B.V 01.10.2018
• Subjects: Biomarkers, Tumor - metabolism; Cancer; Cholesterol; Early Detection of Cancer; Genetics; Humans; Neoplasms - diagnosis; Neoplasms - genetics; Neoplasms - metabolism; Oxysterols; Oxysterols - metabolism; Polymorphism; Risk; Signal Transduction; SIFT; GWAS; GPR; NNK; STARD; UDCA; OSBP; HSD; Genetics; CYP; PFS; EC; SREBP; ERβ; ERα; OSBPL; HCC; SOAT; SERM; MAPK; ER; ESCC; IFAP; BCR; ERAD; CH25H; GIT; CoA; ROR; Smo; CRC; Scap; NGS; NPC; BC; CETP; FXR; ABC; DNMT1; NR; EBI2; NPI; SqC-LC; LXR; HMGCS; Risk; GBC; LCAT; HMGCR; PXR; ORP; RXR; SULT; PCa; EBP; Insig; SNP; LDL; Oxysterols; CXCR2; 25(OH)D; KC; NSCLC; VDR; IL-8RB; HMG-CoA; AEBS; Cholesterol; diHC; QOL; LC; DHCR7; HC; PM; MBTPS; NFE2L1; Cancer; Polymorphism
• ISSN: 0300-9084; 1638-6183
• DOI: 10.1016/j.biochi.2018.04.023

Oxysterols, oxygenated derivatives of cholesterol, are formed in the human body or ingested. Experimental evidence suggests that due to their diverse functions, e.g. modulating the activity of receptors such as liver X receptors, oxysterol-binding and metabolizing proteins, and several ATP binding cassette transporters, oxysterols may contribute to a number of human disorders including cancer. Genetic variability of oxysterol pathways represents another side of this process, affecting carcinogenesis and cancer progression. This review summarizes information about both the physiological role of oxysterol pathway genes and observed associations between their genetic variability and cancer incidence, progression, and therapy outcome. Besides candidate gene studies, results of genome-wide association studies are presented as well. The survey of available data shows some potential genetic biomarkers that, if clinically validated, may allow the stratification of individuals into genetically defined groups for prediction of individual cancer risk and subsequent screening strategies for early diagnosis. [Display omitted] •Oxysterols are oxidized derivatives of cholesterol formed in human body or ingested.•Interactions of oxysterols with some signaling pathways contribute to carcinogenesis.•Link between genetic variability of oxysterol pathways and cancer is underexplored.•This review summarizes associations between oxysterol pathway genes and cancer risk.•Validated genetic biomarkers may help predict cancer risk and enable early diagnosis.