The plasminogen activator inhibitor-1 gene polymorphism in determining the risk of pediatric ischemic stroke--case control and family-based study

Pediatric ischemic stroke, though relatively rare, remains an important medical problem since 20-40% of patients have recurrent strokes and 50-85% of them suffer from long-term neurological deficits. Approximately 20-50% of the affected children have prothrombotic disorders, therefore upon looking f...

Full description

Saved in:
Bibliographic Details
Published inNeuropediatrics Vol. 42; no. 2; p. 67
Main Authors Balcerzyk, A, Żak, I, Emich-Widera, E, Kopyta, I, Iwanicki, T, Pilarska, E, Pienczk-Ręcławowicz, K, Kaciński, M, Wendorff, J, Połatyńska, K
Format Journal Article
LanguageEnglish
Published Germany 01.04.2011
Subjects
Adolescent
Brain Ischemia - complications
Case-Control Studies
Chi-Square Distribution
Child
Child, Preschool
Family Health
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Infant
Infant, Newborn
Plasminogen Activator Inhibitor 1 - genetics
Poland
Polymorphism, Genetic - genetics
Risk Factors
Stroke - etiology
Stroke - genetics
Poland
Online AccessGet more information

Cover

More Information
Summary:Pediatric ischemic stroke, though relatively rare, remains an important medical problem since 20-40% of patients have recurrent strokes and 50-85% of them suffer from long-term neurological deficits. Approximately 20-50% of the affected children have prothrombotic disorders, therefore upon looking for possible genetic causes of the disease we focused on the plasminogen activator inhibitor (PAI-1)--the major inhibitor of fibrinolysis. The aim of the present study was to investigate a possible association between the -675_-674insG PAI-1 gene polymorphism and pediatric ischemic stroke. The study population consisted of 343 individuals: 70 children with ischemic stroke, 140 their biological parents and 133 control children. The PAI-1 gene polymorphism was genotyped using the restriction fragment length polymorphism and was visualized by AgNO₃ staining. The transmission/disequilibrium test showed exactly the same transmission of alleles from parents to the affected children (37:37). The case-control model also did not reveal any statistical significance in alleles and genotypes distribution between patients and control children. The obtained results suggest that the 4 G/5 G polymorphism of the PAI-I gene is not a risk factor of ischemic stroke in Polish children.
ISSN:1439-1899
DOI:10.1055/s-0031-1279785