Effects of different physical factors on osteogenic differentiation

• Published in: Biochimie Vol. 207; pp. 62 - 74
• Main Authors: Peng, Li, Wu, Fanzi, Cao, Mengjiao, Li, Mengxin, Cui, Jingyao, Liu, Lijia, Zhao, Yun, Yang, Jing
• Format: Journal Article
• Language: English
• Published: France Elsevier B.V 01.04.2023
• Subjects: Bone and Bones; Bone formation; Bone Regeneration; Cell Differentiation - physiology; Osteoblasts; Osteogenesis - physiology; Osteogenic differentiation; Physical factors; Physical factors; Bone formation; Bone regeneration; Osteoblasts; Osteogenic differentiation
• ISSN: 0300-9084; 1638-6183
• DOI: 10.1016/j.biochi.2022.10.020

Osteoblasts are essential for bone formation and can perceive external mechanical stimuli, which are translated into biochemical responses that ultimately alter cell phenotypes and respond to environmental stimuli, described as mechanical transduction. These cells actively participate in osteogenesis and the formation and mineralisation of the extracellular bone matrix. This review summarises the basic physiological and biological mechanisms of five different physical stimuli, i.e. light, electricity, magnetism, force and sound, to induce osteogenesis; further, it summarises the effects of changing culture conditions on the morphology, structure and function of osteoblasts. These findings may provide a theoretical basis for further studies on bone physiology and pathology at the cytological level and will be useful in the clinical application of bone formation and bone regeneration technology. •Osteoblasts can sense external physical stimuli.•Osteoblasts can convert physical stimuli into biochemical reactions and ultimately change cell biological functions.•The effects of light, electricity, magnetism, force and sound on osteoblasts and related applications.