NO donors: Focus on furoxan derivatives

The article focuses attention on furoxan derivatives (1,2,5 oxadiazole 2-oxides) as NO donors. Possible mechanisms for NO release from these products in physiological solution and in segments of rabbit femoral artery are briefly considered. The in vitro anti aggregatory activities and the in vitro a...

Full description

Saved in:
Bibliographic Details
Published inPure and applied chemistry Vol. 76; no. 5; pp. 973 - 981
Main Authors Gasco, Alberto, Fruttero, Roberta, Sorba, G., Di Stilo, Antonella, Calvino, R.
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 01.01.2004
Walter de Gruyter GmbH
Subjects
Anticancer properties
Derivatives
Online AccessGet full text

Cover

More Information
Summary:The article focuses attention on furoxan derivatives (1,2,5 oxadiazole 2-oxides) as NO donors. Possible mechanisms for NO release from these products in physiological solution and in segments of rabbit femoral artery are briefly considered. The in vitro anti aggregatory activities and the in vitro and in vivo vasodilating properties of a number of furoxans are examined with particular reference to involvement of NO in these actions. The use of the furoxan system to design new NO donor/drug hybrids is discussed in connection with the problem of the balance between NO- and drug dependent activities of the resulting structures. Whether other biological activities (as yet, little studied) of furoxans, such as their antiparasite, antimicrobial, and antitumoral effects, are NO dependent, is a matter still to be explored.
ISSN:0033-4545
1365-3075
DOI:10.1351/pac200476050973