Neuronal loss in anterior cingulate cortex in spared nerve injury model of neuropathic pain

•SNI causes caspase-dependent apoptosis of ACC neurons.•Blocking apoptosis prevents the loss of ACC inhibition and alleviates mechanical hypersensitivity after SNI.•Apoptosis of ACC neurons is triggered by NMDA receptor activation.

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Bibliographic Details
Published inNeurochemistry international Vol. 118; pp. 127 - 133
Main Authors Tan, Wei, Yao, Wen-Long, Zhang, Bo, Hu, Rong, Wan, Li, Zhang, Chuan-Han, Zhu, Chang
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2018
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Summary:•SNI causes caspase-dependent apoptosis of ACC neurons.•Blocking apoptosis prevents the loss of ACC inhibition and alleviates mechanical hypersensitivity after SNI.•Apoptosis of ACC neurons is triggered by NMDA receptor activation.
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ISSN:0197-0186
1872-9754
DOI:10.1016/j.neuint.2018.06.003