Evaluation of p53 and Ki67 Expression Profiles in Basal Cell Carcinomas in a Usual and an Unusual Location

• Published in: Turk patoloji dergisi Vol. 34; no. 2; pp. 165 - 170
• Main Authors: Süngü, Nuran, Kiran, Merve Meryem, Tatli Doğan, Hayriye, Kiliçarslan, Aydan, Karakök, Emre, Akyol, Mesut
• Format: Journal Article
• Language: English
• Published: Turkey Federation of Turkish Pathology Societies 2018
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Basal cell carcinoma; Biomarkers, Tumor - analysis; Carcinoma, Basal Cell - pathology; Female; Humans; Ki-67 Antigen - analysis; Ki-67 Antigen - biosynthesis; Ki67; Location; Male; Middle Aged; p53; Retrospective Studies; Skin Neoplasms - pathology; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - biosynthesis; Young Adult
• ISSN: 1018-5615; 1309-5730
• DOI: 10.5146/tjpath.2018.01424

Owing to their importance in cell proliferation in cutaneous malignancies, we aimed to immunohistochemically compare the expression profiles of p53 and Ki67 in basal cell carcinoma (BCC) cases in both a usual and an unusual locations in this study. In this study we included 12 in an unusual location of BCC cases and 21 BCC cases in a usual location. Immunohistochemical expression of p53 and Ki67 antibodies were studied in 33 paraffin-embedded tissue specimens of basal cell carcinoma. We compared the p53 and Ki67 staining scores with clinicopathologic features. The tumor size was found to be greater in BCC cases in an unusual location than those in a usual location. The relationship between age and tumor size was also evaluated in both groups and it was found that tumor size increased with age. A comparative study between the two groups showed no difference p53 and Ki67 expression percentages. There was a linear correlation between the Ki67 and p53 marker staining rates (ρ=0.420; p=0.015). In the samples taken from cases in a usual region, there was a linear and moderate relationship between the markers (ρ=0.513; p=0.017). Median tumor diameter results were similar to the marker staining score (p > 0.05). This is the first study comparing the expression profiles of p53 and Ki67 of BCC cases in an unusual and a usual location. No significant difference was found concerning Ki67 and p53 expression levels between the two groups.