Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate and monodentate pseudohalides

• Published in: European journal of medicinal chemistry Vol. 68; pp. 111 - 120
• Main Authors: Milenković, Milica, Bacchi, Alessia, Cantoni, Giulia, Vilipić, Jovana, Sladić, Dušan, Vujčić, Miroslava, Gligorijević, Nevenka, Jovanović, Katarina, Radulović, Siniša, Anđelković, Katarina
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2013
• Subjects: Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antimicrobial activity; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Carboxylic Acids - chemical synthesis; Carboxylic Acids - chemistry; Carboxylic Acids - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Crystallography, X-Ray; Cytotoxicity; DNA, Bacterial - drug effects; Humans; Hydrazines - chemical synthesis; Hydrazines - chemistry; Hydrazines - pharmacology; K562 Cells; Magnetic Resonance Spectroscopy; Models, Molecular; Nickel - chemistry; Nickel(II) complexes; Phosphines - chemical synthesis; Phosphines - chemistry; Phosphines - pharmacology; Pseudohalides; X-ray crystal structures; X-ray crystal structures; Cytotoxicity; Antimicrobial activity; Nickel(II) complexes; Pseudohalides
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2013.07.039

Three square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage. [Display omitted] •Square-planar complexes of Ni(II) with PNO set of donor atoms.•Antifungal and cytotoxic activities.•Selectivity to leukemia cells in comparison to normal cells.•Effect on cell cycle progression in tumor cells.