Power partial-discard strategy to obtain improved performance for simulated moving bed chromatography

•A novel PPD strategy was developed to improve the performance of the SMB process.•The PPD could provide more enhanced performance than the PD operation.•The two variables, DA and DL, played a key role in achieving the desired performance.•The PPD will be useful for attaining high-purity products wi...

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Bibliographic Details
Published inJournal of Chromatography A Vol. 1529; pp. 72 - 80
Main Authors Chung, Ji-Woo, Kim, Kyung-Min, Yoon, Tae-Ung, Kim, Seung-Ik, Jung, Tae-Sung, Han, Sang-Sup, Bae, Youn-Sang
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 22.12.2017
Subjects
Adsorption
Chromatography - instrumentation
Chromatography - methods
Partial-discard
Performance parameters
Purity
Recovery
Reproducibility of Results
Simulated moving bed (SMB) chromatography
Purity
Performance parameters
Simulated moving bed (SMB) chromatography
Partial-discard
Recovery
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Summary:•A novel PPD strategy was developed to improve the performance of the SMB process.•The PPD could provide more enhanced performance than the PD operation.•The two variables, DA and DL, played a key role in achieving the desired performance.•The PPD will be useful for attaining high-purity products with reasonable recoveries. A novel power partial-discard (PPD) strategy was developed as a variant of the partial-discard (PD) operation to further improve the separation performance of the simulated moving bed (SMB) process. The PPD operation varied the flow rates of discard streams by introducing a new variable, the discard amount (DA) as well as varying the reported variable, discard length (DL), while the conventional PD used fixed discard flow rates. The PPD operations showed significantly improved purities in spite of losses in recoveries. Remarkably, the PPD operation could provide more enhanced purity for a given recovery or more enhanced recovery for a given purity than the PD operation. The two variables, DA and DL, in the PPD operation played a key role in achieving the desired purity and recovery. The PPD operations will be useful for attaining high-purity products with reasonable recoveries.
ISSN:0021-9673
1873-3778
DOI:10.1016/j.chroma.2017.10.079