Suppressing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on chocolate self-administration and reinstatement of chocolate seeking in rats
•Saikosaponin A is a major ingredient of the medicinal herb, Bupleurum falcatum.•Saikosaponin A reduced self-administration of a chocolate-flavored beverage in rats.•Saikosaponin A also reduced reinstatement of seeking for a chocolate-flavored beverage.•These results extend the anti-addictive effect...
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Published in | Neuroscience letters Vol. 638; pp. 211 - 217 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier B.V
18.01.2017
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Subjects | |
Online Access | Get full text |
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Summary: | •Saikosaponin A is a major ingredient of the medicinal herb, Bupleurum falcatum.•Saikosaponin A reduced self-administration of a chocolate-flavored beverage in rats.•Saikosaponin A also reduced reinstatement of seeking for a chocolate-flavored beverage.•These results extend the anti-addictive effect of saikosaponin A to a natural stimulus.
Recent lines of experimental evidence have indicated that saikosaponin A (SSA) – a bioactive ingredient of the medicinal plant, Bupleurum falcatum L. – suppressed alcohol, morphine, and cocaine self-administration in rats. The present paper was designed to assess whether the protective properties of SSA on addiction-related behaviors generalize to a hyperpalatable food such as a chocolate-flavored beverage (CFB). To this end, rats were initially trained to lever-respond for CFB [5% (w/v) Nesquik® powder in water] under fixed ratio (FR) 10 (FR10) schedule of reinforcement. Once lever-responding reached stable levels, rats were treated acutely with two different dose ranges of SSA (0, 0.25, 0.5, and 1mg/kg; 0, 1, 2.5, and 5mg/kg; i.p.) and exposed to the FR10 and progressive ratio (PR) schedules of reinforcement in four independent experiments. The effect of acutely administered SSA (0, 0.25, 0.5, and 1mg/kg; i.p.) on cue-induced reinstatement of seeking behavior for CFB was also assessed. Under the FR and PR schedules of reinforcement, treatment with SSA diminished lever-responding for CFB, amount of self-administered CFB, and breakpoint for CFB. All variables were virtually completely suppressed after treatment with 5mg/kg SSA. Treatment with SSA also suppressed reinstatement of CFB-seeking behavior. No dose of SSA altered rat motor-performance, evaluated exposing all rats to an inverted screen test immediately after the self-administration session. These results demonstrate that acute treatment with SSA potently suppressed several addictive-like behaviors motivated by highly hedonic nourishment. These data extend to a highly rewarding natural stimulus the anti-addictive properties of SSA recently disclosed in rats self-administering alcohol, morphine, and cocaine. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/j.neulet.2016.12.019 |