Recurrences in tuberculosis in a cohort of human immunodeficiency virus-infected patients: The influence of highly active antiretroviral therapy

• Published in: Enfermedades infecciosas y microbiologia clinica Vol. 31; no. 4; pp. 227 - 229
• Main Authors: Millet, Juan-Pablo, Orcau, Angels, Casals, Martí, Garcia de Olalla, Patricia, Caylà, Joan A
• Format: Journal Article
• Language: English
• Published: Spain Elsevier Espana 01.04.2013
• Subjects: Adolescent; Adult; Aged; Anti-HIV Agents - therapeutic use; Antiretroviral Therapy, Highly Active; Comorbidity; Female; Follow-Up Studies; Highly active antiretroviral therapy; HIV Infections - drug therapy; HIV Infections - epidemiology; Human immunodeficiency virus; Humans; Infectious Disease; Kaplan-Meier Estimate; Male; Middle Aged; Recaída; Recurrence; Recurrencia; Registries; Relapse; Retrospective Studies; Risk; Spain - epidemiology; Tratamiento antiretroviral de gran actividad; Tuberculosis; Tuberculosis - epidemiology; Virus de la inmunodeficiencia humana; Young Adult; Spain; Highly active antiretroviral therapy; Recurrence; Recurrencia; Relapse; Recaída; Tuberculosis; Tratamiento antiretroviral de gran actividad; Human immunodeficiency virus; Virus de la inmunodeficiencia humana
• ISSN: 0213-005X; 1578-1852
• DOI: 10.1016/j.eimc.2012.08.008

Abstract Background Little is known about recurrent tuberculosis (TB) among HIV-infected patients and the influence of highly active antiretroviral therapy (HAART). Methods A population-based retrospective longitudinal study was conducted on all HIV-infected TB patients in Barcelona (Spain) notified in 1987–2003, and followed up until 2005. TB recurrence and HAART influence were analysed according to calendar period. Results Patients with no-treatment and those in pre-HAART had more risk of TB recurrence (RR: 2.3; CI: 1–5.8 and RR: 4.8; CI: 2–12). Conclusions HAART decreases probability of TB recurrence and should be extended to all cases.