Current trends and future perspectives of nanomedicine for the management of colon cancer

• Published in: European journal of pharmacology Vol. 910; p. 174464
• Main Authors: Wahab, Shadma, Alshahrani, Mohammad Y., Ahmad, Md Faruque, Abbas, Hashim
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.11.2021
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Cell Line, Tumor; Clinical Trials as Topic; Colon cancer; Colonic Neoplasms - diagnosis; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Dendrimers; Disease Models, Animal; Exosomes; Humans; Hydrogels; Liposomes; Micelles; Nanomedicine; Nanomedicine - methods; Nanomedicine - trends; Nanoparticle Drug Delivery System - chemistry; Phytosomes; Xenograft Model Antitumor Assays; Dendrimers; Colon cancer; Hydrogels; Micelles; Phytosomes; Liposomes; Exosomes; Nanomedicine
• ISSN: 0014-2999; 1879-0712; 1879-0712
• DOI: 10.1016/j.ejphar.2021.174464

Colon cancer (CC) kills countless people every year throughout the globe. It persists as one of the highly lethal diseases to be treated because the overall survival rate for CC is meagre. Early diagnosis and efficient treatments are two of the biggest hurdles in the fight against cancer. In the present work, we will review thriving strategies for CC targeted drug delivery and critically explain the most recent progressions on emerging novel nanotechnology-based drug delivery systems. Nanotechnology-based animal and human clinical trial studies targeting CC are discussed. Advancements in nanotechnology-based drug delivery systems intended to enhance cellular uptake, improved pharmacokinetics and effectiveness of anticancer drugs have facilitated the powerful targeting of specific agents for CC therapy. This review provides insight into current progress and future opportunities for nanomedicines as potential curative targets for CC treatment. This information could be used as a platform for the future expansion of multi-functional nano constructs for CC's advanced detection and functional drug delivery. [Display omitted]