Pain-related neurons in the human cingulate cortex

Although it is widely accepted that the cortex participates in pain perception, there is no direct evidence for the existence of cortical neurons that respond to noxious or painful stimuli in humans. Anatomical and neurophysiological studies in animals as well as brain imaging and evoked potential s...

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Published inNature neuroscience Vol. 2; no. 5; pp. 403 - 405
Main Authors Hutchison, W. D, Davis, K. D, Lozano, A. M, Tasker, R. R, Dostrovsky, J. O
Format Journal Article
LanguageEnglish
Published United States 01.05.1999
Subjects
Gyrus Cinguli - cytology
Gyrus Cinguli - physiology
Humans
Neurons - physiology
Pain - physiopathology
Stress, Mechanical
Temperature
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Summary:Although it is widely accepted that the cortex participates in pain perception, there is no direct evidence for the existence of cortical neurons that respond to noxious or painful stimuli in humans. Anatomical and neurophysiological studies in animals as well as brain imaging and evoked potential studies in humans suggest that the anterior cingulate cortex (ACC) is an important area for processing sensory information related to pain. We have now identified single neurons in ACC that respond selectively to painful thermal and mechanical stimuli, supporting a role for the ACC in pain perception.
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ISSN:1097-6256
1546-1726
DOI:10.1038/8065