Boric acid as an efficient catalyst for the synthesis of 1,1-diacetate under solvent-free condition

• Published in: Chinese chemical letters Vol. 20; no. 12; pp. 1453 - 1456
• Main Authors: Shelke, K.F., Sapkal, S.B., Kakade, G.K., Shinde, P.V., Shingate, B.B., Shingare, M.S.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2009; Organic Research Laboratory, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS 431004, India
• Subjects: 1,1-Diacetate; Aromatic and heteroaryl aldehyde; Boric acid; Solvent-free; 化学选择性; 反应条件; 无溶剂条件; 有机溶剂; 醋酸酐; 高效催化剂; Boric acid; Aromatic and heteroaryl aldehyde; 1,1-Diacetate; Solvent-free; 1; 1-Diacetate; Solvent-flee; Aromatic and beteroatyl aldehyde
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2009.07.009

Boric acid （BO3H3） is an inexpensive, efficient and mild catalyst for the synthesis of 1,1-diacetate （acylal） from the various aromatic and heteroaryl aldehydes with acetic anhydride at room temperature under solvent-free condition. The present method does not involve any hazardous organic solvents or catalysts. This method gives notable advantages such as excellent chemoselectivity, mild reaction condition, short reaction times and excellent yield.