Peptides having antimicrobial activity and their complexes with transition metal ions

• Published in: European journal of medicinal chemistry Vol. 143; pp. 997 - 1009
• Main Authors: Jeżowska-Bojczuk, Małgorzata, Stokowa-Sołtys, Kamila
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.01.2018
• Subjects: AMP; Antimicrobial peptide; Metalloantibiotic; Peptide antibiotics; Transition metal ion complexes; BSA; ATCUN; AMP; Metalloantibiotic; HSA; ROS; Peptide antibiotics; Transition metal ion complexes; Antimicrobial peptide
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2017.11.086

Peptide antibiotics are produced by bacterial, mammalian, insect or plant organisms in defense against invasive microbial pathogens. Therefore, they are gaining importance as anti-infective agents. There are a number of antibiotics that require metal ions to function properly. Metal ions play a key role in their action and are involved in specific interactions with proteins, nucleic acids and other biomolecules. On the other hand, it is well known that some antimicrobial agents possess functional groups that enable them interacting with metal ions present in physiological fluids. Some findings support a hypothesis that they may alter the serum metal ions concentration in humans. Complexes usually have a higher positive charge than uncomplexed compounds. This means that they might interact more tightly with polyanionic DNA and RNA molecules. It has been shown that several metal ion complexes with antibiotics promote degradation of DNA. Some of them, such as bleomycin, form stable complexes with redox metal ions and split the nucleic acids chain via the free radicals mechanism. However, this is not a rule. For example blasticidin does not cause DNA damage. This indicates that some peptide antibiotics can be considered as ligands that effectively lower the oxidative activity of transition metal ions. [Display omitted] •Metal ion complexes with non-ribosomal peptide antibiotics.•Metal ion complexes with antimicrobial peptides.•Metal ion as important factor for the proper structure and antibiotic efficiency.•Antimicrobial agents may alter metal ion homeostasis in the organism.