Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity

Three gold(I) linear compounds, sharing the general formula [AuI(LPh )], have been synthesized and characterized. The nature of the ligand has been modified by moving down among some of the elements of group 15, i.e. phosphorus, arsenic and antimony. The structures of derived compounds have been sol...

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Published inJournal of inorganic biochemistry Vol. 251; p. 112452
Main Authors Giorgi, Ester, Mannelli, Michele, Gamberi, Tania, Durante, Maria, Gabbiani, Chiara, Cirri, Damiano, Pratesi, Alessandro
Format Journal Article
LanguageEnglish
Published United States 01.02.2024
Subjects
Anticancer drugs
Metal-based complexes
Gold
Antimony
Arsenic
Auranofin
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Summary:Three gold(I) linear compounds, sharing the general formula [AuI(LPh )], have been synthesized and characterized. The nature of the ligand has been modified by moving down among some of the elements of group 15, i.e. phosphorus, arsenic and antimony. The structures of derived compounds have been solved through XRD and the reactivity behaviour towards selected biomolecules has been investigated through a multi-technique approach involving NMR, high-resolution mass spectrometry and IR. Moreover, the biological activity of the investigated compounds has been comparatively analyzed through classical methodologies and the disclosed differences are discussed in detail.
Bibliography:ObjectType-Article-1
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ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2023.112452