technique for studying the function of an isolated, perfused and ventilated lung in a rat model

We describe a technique which allows perfusion of an isolated, ventilated rat lung with an extracorporeal veno-venous circuit from a support animal. This model provides stable and reliable function of the isolated lung for up to 3 h, thus overcoming some of the disadvantages of previous models. It m...

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Bibliographic Details
Published inLaboratory animals (London) Vol. 29; no. 1; pp. 96 - 101
Main Authors Hopkinson, D.N, Odom, N.J, Eloakley, R.M, Au, J, Hooper, T.L
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 1995
Subjects
animal models
animal physiology
Animals
In Vitro Techniques
Lung - blood supply
Lung - physiology
lung function
lungs
Male
Models, Biological
Perfusion
preservation
Rats
Rats, Sprague-Dawley
Reperfusion Injury
Respiration, Artificial
Tissue Preservation
PRESERVATION
LUNG
MODEL
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Summary:We describe a technique which allows perfusion of an isolated, ventilated rat lung with an extracorporeal veno-venous circuit from a support animal. This model provides stable and reliable function of the isolated lung for up to 3 h, thus overcoming some of the disadvantages of previous models. It may prove a potentially useful model for assessing ischaemic lung injury.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0023-6772
1758-1117
DOI:10.1258/002367795780740456