Improved Real-Time Puff-by-Puff GC-MS System for Whole Smoke Analysis

An automated puff-by-puff mainstream smoke (MSS) system is developed to monitor real-time whole smoke in mainstream cigarette smoke using gas chromatography (GC)-mass spectrometry (MS). The whole-smoke analysis is based on automated sample collection and injection into the GC-MS system. The importan...

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Bibliographic Details
Published inJournal of chromatographic science Vol. 44; no. 4; pp. 209 - 213
Main Authors Huang, C.B., Self, David A.
Format Journal Article
LanguageEnglish
Published Niles, IL Oxford University Press 01.04.2006
Preston Publications
Subjects
Biological and medical sciences
Medical sciences
Tobacco, tobacco smoking
Toxicology
Automation
Chemical analysis
Coupled method
Volatile organic compound
Low volatile compound
Nicotiana tabacum
Real time
Mainstream smoke
Cigarette
Gas chromatography
Tobacco
Dicotyledones
Angiospermae
Spermatophyta
Solanaceae
Sampling
Mass spectrometry
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Summary:An automated puff-by-puff mainstream smoke (MSS) system is developed to monitor real-time whole smoke in mainstream cigarette smoke using gas chromatography (GC)-mass spectrometry (MS). The whole-smoke analysis is based on automated sample collection and injection into the GC-MS system. The important feature of this system is the real-time rapid analysis that is simple, sensitive, precise, flexible, and exhibits low carryover of volatile and semivolatile smoke constituents. The system is equipped with an automated sampling and switching valve and a smoking machine. The key improvements of the system, as compared with current and alternative methodologies, include minimizing variations caused by operator sampling techniques, the real-time analysis of MSS, the detection of flavorants in MSS from a single puff of cigarette smoke, the ability to analyze numerous smoke constituents from either whole smoke or the gas phase of a single puff, the ability to monitor a few selected smoke constituents in whole smoke using multiple puffs, and its good feasibility compared with solvent extraction and impinger trapping procedures for volatile organic compounds in MSS. System configuration and sampling methodologies are described. Sensitivity, flexibility, precision, feasibility, carryover, and applications of the system are discussed.
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ISSN:0021-9665
1945-239X
DOI:10.1093/chromsci/44.4.209