Sleep in thyrotoxicosis

• Published in: Indian journal of endocrinology and metabolism Vol. 15; no. 1; pp. 23 - 26
• Main Authors: Sridhar, GR, Putcha, Venkata, Lakshmi, G
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 2011; Medknow Publications; Wolters Kluwer Medknow Publications
• Subjects: Analysis; Difficulty in falling asleep; hypothyroidism; logistic regression; Original; Sleep; Thyroid diseases; Difficulty in falling asleep; logistic regression; hypothyroidism
• ISSN: 2230-8210; 2230-9500; 2230-9500
• DOI: 10.4103/2230-8210.77578

Pattern of sleep in hyperthyroid state / thyrotoxicosis has not been systematically studied. It is being characterized as poor without further elaboration. We analyzed the pattern of sleep in a large sample of individuals with thyrotoxicosis who came to our endocrine center in southern India. We identified individuals with the diagnosis of 'thyrotoxicosis' from our electronic medical record database, and evaluated clinical parameters and pattern of their sleep: difficulty in falling asleep (DFA), difficulty in maintaining sleep (DMS), excess daytime sleepiness). In the first phase, univariate analysis with logistic regression was performed. Multivariate logistic regression was performed in the next phase on variables with a P-value < 0.1: these were considered as potential categories/ variables. In model response variable with DFA, multivariate logistic regression predicted that subjects with abnormal appetite (more 1.7 or less 2.2), change in bowel motion (loose 1.5 or constipation 2.8), in mood (easy loss of temper 3.4), change of voice -- hoarse 7.4 or moderately hoarse 3.1), tended to have higher chances of difficulty in falling asleep (DFA). Patients with tremor (yes = 5.4) had greater likelihood of difficulty in maintaining sleep (DMS). Individuals with hyperthyroidism/thyrotoxicosis principally had difficulty in falling asleep DFA, which was related to hyperkinetic features.