Clinico Hematological Profile and Phase Distribution of Chronic Myeloid Leukemia

• Published in: Biology and medicine Vol. 7; no. 5; p. 1
• Main Authors: Chang, Farzana, Qazi, Riaz Ahmad, Khan, Mehrab, Baloch, Sarmad
• Format: Journal Article
• Language: English
• Published: Aligarh HATASO Enterprises, LLC 2015; HATASO Enterprises LLC
• Subjects: Chronic myeloid leukemia; Distribution; Hematology; Medical research; Physiological aspects
• ISSN: 0974-8369; 0974-8369
• DOI: 10.4172/0974-8369.1000257

Objectives: To evaluate the Clinico hematological profile based on the age, sex and Clinico hematological presentations and frequencies of three phases of chronic myeloid leukemia (CML), This study highlight the Ph positively by real time polymerase chain reaction (RT-PCR) technique contribute towards understanding the disease biology, and have important implications for diagnosis and management of CML patients. Study design: This is an experimental and observational study. Place and duration: This study was conducted in medical ward and pathology department of Peoples University of Medical and Health Sciences for women (PUMHS-W) Nawabshah from June 2013 to June 2014. Materials and methods: Total 83 patients including 52 male, 31 female at their age ranges between 23 and 57 years admitted in medical ward of PUMHS hospital were selected for study. The clinical history and physical examination of these patients were noted. All the blood samples and bone marrow biopsy sent to the pathology department of PUMHS for the analysis of complete blood count, peripheral blood and bone marrow examination for the diagnosis of three phases of chronic myeloid leukemia. Results: Out of 83 patients, 52 were male and 31 were female with male to female ratio of 1.6:1, the mean age of these subjects was 39.5 [+ or -] 16.5 years. The mean total leukocyte counts, platelet counts, hemoglobin levels and marrow blast frequencies were 121,000 [+ or -] 35,000/cmm, 285,000 [+ or -] 122,000/cmm, 7.5 [+ or -] 4.9 and 15 [+ or -] 9 respectively. The majority of patients 62 (74.6%) were classified in the chronic phase (CP), 17 (20.4%) in the accelerated phase (AP) and 3 (5.0%) in blast crisis (BC). The most frequent patient age ranges were 21-30 years for CP, 41-50 years for AP and 41-50 years for BC. Conclusion: This study concluded that most CML patients are from a younger age group (33-47 years). Males were more commonly affected than the females. The detection of ph chromosome positively by resent and advanced RT-PCR technique is mandatory for the diagnosis and treatment of CML patients. Keywords: Chronic myeloid leukemia; Phase distribution; Response to therapy; RT-PCR; Philadelphia chromosome