Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse

• Published in: Neurourology and urodynamics Vol. 31; no. 1; pp. 109 - 114
• Main Authors: Bortolini, Maria A.T., Shynlova, Oksana, Drutz, Harold P., Castro, Rodrigo A., Girão, Manoel J.B.C., Lye, Stephen, Alarab, May
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2012
• Subjects: actin; Actins - genetics; Actins - metabolism; Adult; Aged; Aging - metabolism; Aging - pathology; Biopsy; Calmodulin-Binding Proteins - genetics; Calmodulin-Binding Proteins - metabolism; Case-Control Studies; Down-Regulation - physiology; Female; Gene Expression Regulation - physiology; Humans; menopause; Middle Aged; Muscle Contraction - genetics; Muscle Contraction - physiology; Muscle Proteins - genetics; Muscle Proteins - metabolism; Muscle, Smooth - metabolism; myosin; Myosin Heavy Chains - genetics; Myosin Heavy Chains - metabolism; Pelvic Organ Prolapse - genetics; Pelvic Organ Prolapse - metabolism; Pelvic Organ Prolapse - pathology; POP; Postmenopause - genetics; Postmenopause - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; smooth muscle; Tropomyosin - genetics; Tropomyosin - metabolism; vagina; Vagina - metabolism; Vagina - pathology

Aims We hypothesize that the expression of genes encoding vaginal smooth muscle (SM) contractile proteins is altered in patients with pelvic organ prolapse (POP) and is influenced by age and menopausal status. We aim to analyze the expression of SM‐myosin heavy chain (MHY11), caldesmon (CALD1), SM g...