Effect of Shenqi Compound Formula on PPARγ in White Adipose Tissue of Rats with Macrovascular Lesion in Early Stage of Diabetes

• Published in: Journal of traditional Chinese medicine Vol. 28; no. 2; pp. 134 - 138
• Main Author: 张红敏 谢春光 陈世伟 谢毅强 王友京（译）
• Format: Journal Article
• Language: English
• Published: West China Hospital of Sichuan University,Chengdu 610041,China%Chengdu University of Traditional Chinese Medicine,China%Food and Drug Administration of Henan,China 01.06.2008
• Subjects: 活性受体; 糖尿病; 过氧化物酶体; Peroxisome proliferatorsactivated receptor γ(PPARγ); TypelI Diabetes; Shenqi Compound Formula; Macrovascular lesion
• ISSN: 0255-2922
• DOI: 10.1016/S0254-6272(08)60032-1

Objective： To investigate the effect of Shenqi Compound Formula （SCF） on peroxisome proliferators- activated receptor γ （PPARγ） in white adipose tissue of rats with macrovascular lesion in early stage of diabetes. Methods： Corresponding treatment was given to rats in model group, Ramipril group, normal control group, low dosage SCF group and high dosage SCF group respectively for 32 days. The expressions of PPARγ and adiponectin Messenger RNA （mRNA） were detected by real-time reverse transcriptase poly- merase chain reaction. Results： The expressions of PPARγ and adiponectin mRNA increased significantly in both low and high dosage SCF groups as compared with the model group, and a positive linear correlation was found between the expressions of PPARγ and adiponectin mRNA. Conclusions： SCF can prevent macrovascular lesion in early stage of diabetes, which is possibly related with up-regulating expressions of PPARγ and activating PPARγ.