Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain

• Published in: International journal of nanomedicine Vol. 13; no. T-NANO 2014 Abstracts; pp. 97 - 100
• Main Authors: Patel, Bhavin K, Parikh, Rajesh H, Patel, Nilesh
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press 2018
• Subjects: Administration, Intravenous; Animals; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - pharmacokinetics; Brain - drug effects; Brain Targeting; Cell Line; Chromatography, High Pressure Liquid; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug Delivery Systems - methods; HIV (Human Immune Deficiency Virus); Lactic Acid - chemistry; Lamivudine - administration & dosage; Lamivudine - pharmacokinetics; Macrophage Targeting; Macrophages - drug effects; Mannose - chemistry; Mannosylated PLGA Nanoparticles; Microscopy, Confocal; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Polyglycolic Acid - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Short Report; Tissue Distribution; human immunodeficiency virus; brain targeting; macrophage targeting; mannosylated poly(lactic-co-glycolic acid) nanoparticles
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S124692

Mannosylated polymeric nanoparticles (NPs) enable improvement of brain bioavailability and reduction of dosing due to efficient drug delivery at the target site. Mannose receptors are present on the surface of macrophages, and therefore, in this study, it is expected that mannosylated NPs of anti-human immunodeficiency virus drug may target the macrophages, which may improve the therapeutic outcome and reduce the toxicity of antiretroviral bioactives. Poly(lactic-co-glycolic acid) (PLGA) and mannosylated-PLGA NPs (Mn-PLGA NPs) were prepared and administered by intravenous route in a dose of 10 mg/kg. After predetermined time period, the pharmacokinetics and biodistribution of NPs were analyzed using high-performance liquid chromatography and confocal microscopy, respectively. Results of this study indicated that Mn-PLGA NPs would be a promising therapeutic system for efficient delivery of the drug into brain macrophages.