Towards a magnetic microarray for sensitive diagnostics

We present proof-of-concept experiments and modeling towards a high-sensitivity magnetic microarray which “tags” a DNA fragment (or other biological samples) with a high-moment magnetic nanoparticle (NanoTag), which is in turn detected by a high-sensitivity spin valve (SV) or magnetic tunnel junctio...

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Published inJournal of magnetism and magnetic materials Vol. 293; no. 1; pp. 731 - 736
Main Authors Wang, Shan X., Bae, Seung-Young, Li, Guanxiong, Sun, Shouheng, White, Robert L., Kemp, Jennifer T., Webb, Chris D.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 01.05.2005
Elsevier Science
Subjects
Biodetection
Condensed matter: electronic structure, electrical, magnetic, and optical properties
DNA detection
Exact sciences and technology
Giant magnetoresistance
MagArray
Magnetic microarray
Magnetic properties and materials
Magnetic tunnel junction
Magnetotransport phenomena, materials for magnetotransport
Nanoparticles
NanoTag
Physics
Small particles and nanoscale materials
Spin valve
Studies of specific magnetic materials
Nanoparticles
Spin valve
Biodetection
MagArray
DNA detection
Magnetic microarray
NanoTag
Magnetic tunnel junction
Magnetic moments
Giant magnetoresistance
Magnetic particles
High spin states
Tunnel junction
Modelling
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Summary:We present proof-of-concept experiments and modeling towards a high-sensitivity magnetic microarray which “tags” a DNA fragment (or other biological samples) with a high-moment magnetic nanoparticle (NanoTag), which is in turn detected by a high-sensitivity spin valve (SV) or magnetic tunnel junction (MTJ) detector array. The detector can count the number of magnetic tags with a resolution of 1–20 magnetic NanoTags, potentially counting individual biomolecules.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0304-8853
DOI:10.1016/j.jmmm.2005.02.054