Novel drug delivery systems based on triaxial electrospinning based nanofibers

• Published in: Reactive & functional polymers Vol. 163; p. 104895
• Main Authors: Ghosal, Kajal, Augustine, Robin, Zaszczynska, Angelika, Barman, Mrinmoy, Jain, Amrita, Hasan, Anwarul, Kalarikkal, Nandakumar, Sajkiewicz, Pawel, Thomas, Sabu
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.06.2021; Elsevier BV
• Subjects: Biomolecules; Complex nanostructures; Desired functional performance; Drug delivery; Drug delivery systems; Electrospinning; Kinetics; Nanofibers; Nanomaterials; Nanotechnology; Pore size; Sustained release; Sustained/controlled release; Triaxial electrospinning; Desired functional performance; Sustained/controlled release; Drug delivery; Triaxial electrospinning; Complex nanostructures
• ISSN: 1381-5148; 1873-166X
• DOI: 10.1016/j.reactfunctpolym.2021.104895

Electrospinning is a widely investigated process for forming nanofibers. Nanofibers in drug delivery systems are extensively tested due to its remarkable properties e.g. small pore size or large surface area. Recent articles have informed about formation of fibers using triaxial electrospinning in drug delivery systems. This paper summarizes the process of triaxial electrospinning and its application in drug delivery. Triaxial electrospinning has advantages in forming complex nanostructures for specific drug delivery applications. This paper summarizes the possibility to use triaxial electrospinning to resolve the problem of limited drug solubility, to protect biomolecules from hostile environment, and to control drug release kinetics, with the possibility of loading of various drugs. There are literature data evidencing the possibility to achieve sustained release with a border case of zero rate order kinetics. There is no doubt that triaxial electrospinning opens a new way to develop sophisticated nanomaterials for achieving the desired functional performances and to expand the applications in the drug delivery area. Triaxial electrospinning method is interdisciplinary area with great potential in nanotechnology. Triaxial electrospun fibers in drug delivery applications. [Display omitted] •The process of tri-axial electrospinning and its application in drug delivery has been highlighted here.•Tri-axial electrospinning has evident advantages in creating complex nanostructures.•Triaxial electrospinning process is able overcome the problem of limited drug solubility, to protect biomolecules.•Tri-axial process is able to control drug release kinetics, with possibility of loading of multiple drugs.