Light-controlled reactive oxygen species (ROS)-producible polymeric micelles with simultaneous drug-release triggering and endo/lysosomal escape

A doxorubicin (DOX)-loaded and light-induced ROS-producing polymeric micelle (D-LRPM), in which light triggers simultaneous DOX-release and endo/lysosomal escape, produces a powerful, spatiotemporally controllable, therapeutic efficacy for tumor treatment.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 52; no. 13; pp. 2839 - 2842
Main Authors Kim, Kihong, Lee, Chung-Sung, Na, Kun
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Doxorubicin
Effectiveness
Light
Micelles
Oxygen
Polymers - metabolism
Reactive Oxygen Species - metabolism
Tumors
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Summary:A doxorubicin (DOX)-loaded and light-induced ROS-producing polymeric micelle (D-LRPM), in which light triggers simultaneous DOX-release and endo/lysosomal escape, produces a powerful, spatiotemporally controllable, therapeutic efficacy for tumor treatment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc09239f