Optimizing extracorporeal shock wave with the orthogonal array design in the treatment of the spasticity of cerebral palsy

• Published in: Journal of Neurorestoratology Vol. 10; no. 2; p. 100004
• Main Authors: Zhang, Chuntao, Cheng, Jixiang, Zhao, Wenjian, Liu, Zhenhuan, Qian, Xuguang, Zhao, Yong, Jin, Bingxu, Zhou, Yuan
• Format: Journal Article
• Language: English
• Published: Elsevier 01.06.2022
• Subjects: cerebral palsy; extracorporeal shock wave; muscle spasm; orthogonal array design
• ISSN: 2324-2426; 2324-2426
• DOI: 10.1016/j.jnrt.2022.100004

ObjectiveTo study the dose-response relationship between different treatment parameters of extracorporeal shock wave (ESW) and their effects on spasticity in children with cerebral palsy by the orthogonal design and to select the best parameter scheme for clinical efficacy.MethodsFrom March 2020 to December 2020, 80 children with spastic cerebral palsy were randomly divided into eight groups of 10 cases. Patients in each group received ESW with varying wave intensities (A), wave frequencies (B), number of shocks (C), and treatment frequencies (D), which were determined by a 4-factor-2-level orthogonal array design. Modified Ashworth Scale (MAS) and GMFM were scored before and after the study, and the difference during the study was calculated to evaluate the performance of each group.ResultsThe R-value of ΔMAS was RA > RD > RC > RB and that of ΔGMFM was RA > RC > RD > RB. The influence of the two levels for each factor was A1 > A2, B2 > B1, C2 > C1, D2 > D1. By the analysis of variance, the differences in factors A, C, and D were statistically significant (P ConclusionESW is an effective treatment for spastic cerebral palsy and is worthy of clinical application.