Hydroxyespintanol and schefflerichalcone: two new compounds from Uvaria scheffleri

• Published in: Journal of natural medicines Vol. 64; no. 1; pp. 75 - 79
• Main Authors: Ichimaru, Momoyo, Nakatani, Noriyoshi, Moriyasu, Masataka, Nishiyama, Yumi, Kato, Atsushi, Mathenge, Simon G., Juma, Francis D., ChaloMutiso, Patrick B.
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 2010
• Subjects: Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biomedical and Life Sciences; Biomedicine; Chalcones - isolation & purification; Chalcones - pharmacology; Complementary & Alternative Medicine; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Promyelocytic, Acute - drug therapy; Medicinal Chemistry; Pharmacology/Toxicology; Pharmacy; Phenylpropionates - isolation & purification; Phenylpropionates - pharmacology; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Roots; Plant Sciences; Solvents - chemistry; Spectrum Analysis; Uvaria - chemistry; Schefflerichalcone; Hydroxyespintanol; Cytotoxicity against HL-60
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-009-0358-0

A chemical investigation of the petroleum ether extract and chloroform extract of the root of Uvaria scheffleri Diels (Annonaceae) led to the isolation of two new compounds, named hydroxyespintanol ( 1 ) and schefflerichalcone ( 2 ), together with eight known compounds ( 3 – 10 ). The structural elucidation of compounds 1 and 2 by spectroscopic studies is described. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was studied. Among these, 2′-hydroxy-3′,4′,6′-trimethoxychalcone ( 5 ) exhibited cytotoxicity (IC 50 12 µM), and espintanol ( 3 ), which was the main ingredient, also showed some cytotoxicity (IC 50 44 µM).