Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates d...

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Published inBeilstein journal of organic chemistry Vol. 19; no. 1; pp. 212 - 216
Main Authors Lerch, Swantje, Fritsch, Stefan, Strassner, Thomas
Format Journal Article
LanguageEnglish
Published Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 23.02.2023
Beilstein-Institut
Subjects
Acids
Acylation
Benzene
Catalysis
Catalysts
Chemistry
Chloride
Ferric chloride
friedel–crafts acylation
Full Research Paper
homogeneous catalysis
Hydrocarbons
ionic liquids
iron catalysis
taails
Friedel–Crafts acylation
ionic liquids
iron catalysis
homogeneous catalysis
TAAILs
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Summary:An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.19.20