Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element

The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5′-flanking region was sequenced and found to have promoter activity in human osteoblasts. The sequence contains four clustered transcription start sites and three retinoic acid response elements (RAREs) with widely spaced ha...

Full description

Saved in:
Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1518; no. 1; pp. 145 - 151
Main Authors Dailly, Yves P., Zhou, Yuehua, Linkhart, Thomas A., Baylink, David J., Strong, Donna D.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 19.03.2001
Subjects
Animals
Base Sequence
DNA, Complementary
Humans
Insulin-Like Growth Factor Binding Protein 6 - genetics
Mice
Molecular Sequence Data
Osteoblast
Osteoblasts
Promoter
Promoter Regions, Genetic
Rats
Response Elements
Retinoic acid
Retinoids - metabolism
Sequence Homology, Nucleic Acid
Transcription
Tumor Cells, Cultured
Promoter
Osteoblast
Transcription
Retinoic acid
Online AccessGet full text

Cover

More Information
Summary:The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5′-flanking region was sequenced and found to have promoter activity in human osteoblasts. The sequence contains four clustered transcription start sites and three retinoic acid response elements (RAREs) with widely spaced half-sites. Only the proximal DR15 RARE was functional. Retinoids increased IGFBP-6 promoter activity up to 3-fold.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/S0167-4781(01)00192-0