Resistance to HIV-1 infection among highly exposed sex workers in Nairobi: what mediates protection and why does it develop?

Variability in susceptibility to infection and disease caused by infectious agents is a characteristic of all populations. Among susceptible individuals exposed to an infection, not all become infected and among infected individuals, not all develop disease. It seems logical that variability in susc...

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Bibliographic Details
Published inImmunology letters Vol. 66; no. 1; pp. 27 - 34
Main Authors Plummer, Francis A., Ball, T.Blake, Kimani, Joshua, Fowke, Keith R.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.1999
Subjects
AIDS/HIV
Cohort Studies
Female
HIV Infections - epidemiology
HIV Infections - immunology
HIV-1
HIV-1 - immunology
Humans
Immunity
Immunity, Cellular - immunology
Immunity, Innate - immunology
Kenya - epidemiology
Male
MHC
Prostitutes
Resistance
Sex Work
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Helper-Inducer - immunology
HIV-1
Resistance
MHC
Immunity
Prostitutes
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Summary:Variability in susceptibility to infection and disease caused by infectious agents is a characteristic of all populations. Among susceptible individuals exposed to an infection, not all become infected and among infected individuals, not all develop disease. It seems logical that variability in susceptibility to infection and disease would apply to infection and disease with human immunodeficiency viruses. However, until recently, it has been generally held that there is no natural immunity to HIV-1 and that once infected, all individuals would ultimately succumb to AIDS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0165-2478
1879-0542
DOI:10.1016/S0165-2478(98)00182-5