Advanced tumor organoid bioprinting strategy for oncology research

• Published in: Materials today bio Vol. 28; p. 101198
• Main Authors: Cui, Xiangran, Jiao, Jianhang, Yang, Lili, Wang, Yang, Jiang, Weibo, Yu, Tong, Li, Mufeng, Zhang, Han, Chao, Bo, Wang, Zhonghan, Wu, Minfei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2024; Elsevier
• Subjects: Bioprinting; Oncology research; Organoids; Review; Tissue engineering; Tumor models; Tumor models; Bioprinting; Oncology research; Organoids; Tissue engineering
• ISSN: 2590-0064; 2590-0064
• DOI: 10.1016/j.mtbio.2024.101198

Bioprinting is a groundbreaking technology that enables precise distribution of cell-containing bioinks to construct organoid models that accurately reflect the characteristics of tumors in vivo. By incorporating different types of tumor cells into the bioink, the heterogeneity of tumors can be replicated, enabling studies to simulate real-life situations closely. Precise reproduction of the arrangement and interactions of tumor cells using bioprinting methods provides a more realistic representation of the tumor microenvironment. By mimicking the complexity of the tumor microenvironment, the growth patterns and diffusion of tumors can be demonstrated. This approach can also be used to evaluate the response of tumors to drugs, including drug permeability and cytotoxicity, and other characteristics. Therefore, organoid models can provide a more accurate oncology research and treatment simulation platform. This review summarizes the latest advancements in bioprinting to construct tumor organoid models. First, we describe the bioink used for tumor organoid model construction, followed by an introduction to various bioprinting methods for tumor model formation. Subsequently, we provide an overview of existing bioprinted tumor organoid models. Characteristics and applications of bioprinting in constructing tumor organoid models. [Display omitted] •Bioprinting is a pioneering technology to construct tumor organoid models that more realistically reflect in vivo tumor characteristics.•Advanced biomaterials can precisely replicate the arrangement of tumor cells, providing a more realistic characterization of the in vivo tumor microenvironment.•This review highlights the various options of advanced biomaterials and combined bioprinting methods in constructing tumor organoid models for oncology reaearch.