Genetics of nervous system tumors

Genetic aberrations are being defined for the various glial tumors. Astrocytic tumors can evolve by two different pathways. The genetic aberrations now being defined for these two pathways are different and can be associated with the grade of malignancy. In oligodendrogliomas, the genetic lesions di...

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Bibliographic Details
Published inHematology/oncology clinics of North America Vol. 15; no. 6; p. 961
Main Author Shapiro, J R
Format Journal Article
LanguageEnglish
Published United States 01.12.2001
Subjects
Astrocytoma - genetics
Brain Neoplasms - genetics
Central Nervous System Neoplasms - genetics
Ependymoma - genetics
Glioblastoma - genetics
Glioma - genetics
Humans
Oligodendroglioma - genetics
Spinal Cord Neoplasms - genetics
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Summary:Genetic aberrations are being defined for the various glial tumors. Astrocytic tumors can evolve by two different pathways. The genetic aberrations now being defined for these two pathways are different and can be associated with the grade of malignancy. In oligodendrogliomas, the genetic lesions differ from the astrocytic tumors, and several markers have been linked to chemosensitivity response and survival. Genetic aberrations in ependymomas also differ from the astrocytic tumors or oligodendrogliomas. Although additional cases are needed to study the genetic aberrations, the abnormalities identified suggest that spinal cord tumors carry different markers than intracranial tumors and that the markers within the cranium may be different based on their location.
ISSN:0889-8588
DOI:10.1016/S0889-8588(05)70262-8