Small doses of capsaicin given intragastrically inhibit gastric basal acid secretion in healthy human subjects

• Published in: Journal of physiology, Paris Vol. 93; no. 5; pp. 433 - 436
• Main Authors: Mózsik, Gyula, Debreceni, András, Abdel-Salam, Omar M.E., Szabó, Imre, Figler, Mária, Ludány, Andrea, Juricskay, István, Szolcsányi, Janos
• Format: Journal Article
• Language: English
• Published: France Elsevier Ltd 01.11.1999
• Subjects: Adult; Afferent Pathways - drug effects; Afferent Pathways - physiology; capsaicin; Capsaicin - administration & dosage; Capsaicin - pharmacology; dose-response curves; Dose-Response Relationship, Drug; Female; Gastric Acid - secretion; Gastric Juice - drug effects; Gastric Juice - secretion; Gastric Mucosa - drug effects; Gastric Mucosa - innervation; Gastric Mucosa - physiology; human gastric basal secretion; Humans; inhibition of basal secretion in healthy human subjects; Intubation, Gastrointestinal; Male; inhibition of basal secretion in healthy human subjects; human gastric basal secretion; dose-response curves; capsaicin
• ISSN: 0928-4257; 1769-7115
• DOI: 10.1016/S0928-4257(99)00117-5

Although the direct inhibitory effect of small dose of capsaicin on gastric secretory responses was proved in animal observations, the role of capsaicin-sensitive afferent nerves (CSAN) and the effect of capsaicin applied in small and high doses on gastric secretion in human has not been clarified yet. In this study we investigated the influence of different small doses (100–800 μg) of capsaicin given intragastrically through an orogastric tube on gastric basal secretory responses in 10 healthy human subjects. Gastric basal secretory responses (volume, H +-concentration, H +-output) were measured from the suctions of gastric juice for a 1-h period. It has been found that: a) capsaicin dose-dependently inhibited the volume and H +-output of gastric juice; b) ID 50 was found to be about 400 μg for capsaicin on gastric acid secretion; c) the time interval for capsaicin-induced gastric inhibition existed for about 1 h indifferently from the higher dose (800 μg) of capsaicin given after. It has been concluded that the capsaicin (given in small doses) inhibits the gastric basal acid output via stimulation of the inhibition of capsaicin sensitive afferent nerves.