Radiofrequency Ablation of Renal Cell Carcinoma: Part 2, Lessons Learned with Ablation of 100 Tumors

• Published in: American journal of roentgenology (1976) Vol. 185; no. 1; pp. 72 - 80
• Main Authors: Gervais, Debra A, Arellano, Ronald S, McGovern, Francis J, McDougal, W. Scott, Mueller, Peter R
• Format: Journal Article
• Language: English
• Published: Leesburg, VA Am Roentgen Ray Soc 01.07.2005; American Roentgen Ray Society
• Subjects: Aged; Biological and medical sciences; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - surgery; Catheter Ablation - statistics & numerical data; Colon - pathology; Female; Follow-Up Studies; Humans; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Kidney Tubules, Collecting - pathology; Kidneys; Magnetic Resonance Imaging; Male; Medical sciences; Neoplasm, Residual; Nephrology. Urinary tract diseases; Postoperative Complications - epidemiology; Radiography, Interventional; Retrospective Studies; Tomography, X-Ray Computed; Tumors of the urinary system; Kidney disease; Urinary system disease; Carcinoma; Instrumentation therapy; Thermal ablation; Grawitz tumor; Malignant tumor
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/ajr.185.1.01850072

The objective of our study was to review radiofrequency ablation of 100 renal tumors and lessons learned with respect to electrode approach, effects on collecting system, bowel proximity, and patterns of residual disease. Over 6 years, 100 renal tumors in 85 patients underwent radiofrequency ablation. Images were reviewed to determine the following: effect of initial electrode approach at and parallel to the tumor-kidney interface; effect of collecting system proximity to the tumor and to the zone of ablation; bowel proximity to the tumor and strategies to protect bowel; patterns of residual disease; and approaches at subsequent sessions. The initial placement of the electrode at and parallel to the tumor-kidney interface did not result in significantly fewer overlapping ablations (p = 0.91) or a lower rate of residual disease (p = 0.86). Direct contiguity of tumor or zone of ablation to the collecting system did not increase the complication rate. However, obscuration of calyces by a central tumor was a significant predictor of collecting system hemorrhage necessitating treatment (p < 0.001) seen in three of nine tumors obscuring calyces. Clinically significant urine leaks were rare (1/100) and related to downstream obstruction. There were no bowel complications despite the fact that 27 of the tumors were within 1 cm of bowel. Protective strategies progressed from reliance on electrode positioning to hydrodissection. Residual patterns were predominantly nodules or crescents, and straight electrodes were commonly used to approach residual disease. Initial electrode position at and parallel to the tumor-kidney interface does not result in less difficult or more successful ablations. Contiguity of tumor or zone of ablation to the collecting system does not increase the risk of complications, but obscuration of calyces does. Bowel complications are rare, and protection with hydrodissection is becoming more common. Residual tumor presents as nodules or crescents of persistent enhancement.